2024-05-20by admin0

L-tryptophan structural formula

Structural formula

Business number 01HB
Molecular formula C11H12N2O2
Molecular weight 204.23

L-2-amino-3-indolylpropionic acid,

L-Aminoindolepropionic acid,

L-trypsin amino acid,


(S)-2-Amino-3-indolylpropanoic acid,


L-a-Aminoindole-3-propionic acid,

amino acid drugs,


Biochemical reagents

Numbering system

CAS number:73-22-3

MDL number:MFCD00064340

EINECS number:200-795-6

RTECS number:YN6130000

BRN number:86197

PubChem number:24278135

Physical property data

1. Characteristics: There are three isomers. The levorotatory body is a flaky crystal, tasteless.

2. Density (g/mL, 25/4℃): 1.362

3. Relative vapor density (g/mL, air=1): Uncertain

4. Melting point (ºC): 289-290 (dec.)(lit.)

5. Boiling point (ºC, normal pressure): Uncertain

6. Boiling point (ºC, 5.2 kPa): Uncertain

7. Refractive index: -32 ° (C=1, H2O)

8. Flash point (ºC): Uncertain


9. Specific optical rotation (º): -31.1 º (c=1, H20)

10. Autoignition point or ignition temperature (ºC): Uncertain

11. Vapor pressure (kPa, 25 ºC): Uncertain

12. Saturated vapor pressure (kPa, 60 ºC): Uncertain

13. Heat of combustion (KJ/ mol): Uncertain

14. Critical temperature (ºC): Uncertain

15. Critical pressure (KPa): Uncertain

16. Oil and water ( Log value of the partition coefficient (octanol/water): Uncertain

17. Explosion upper limit (%, V/V): Uncertain

18. Explosion lower limit (%, V/ V): Uncertain

19. Solubility: Slightly soluble in water (1.14%, 25℃) and ethanol. Soluble in dilute acid or alkali (20% NH3: 0.1 g/mL at 20 °C, clear, colorless), insoluble in chloroform and ether

Toxicological data


Ecological data


Molecular structure data

5. Molecular property data:

1. Molar refractive index: 57.76

2. Molar volume (cm3/mol): 149.8

3. Isotonic specific volume (90.2K): 435.3

4. Surface tension (dyne/cm): 71.1

5. Polarizability (10-24cm3): 22.90

Compute chemical data

1. Reference value for hydrophobic parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 3

3. Number of hydrogen bond acceptors: 3

4. Number of rotatable chemical bonds: 3

5. Number of tautomers: none

6. Topological molecule polar surface area 79.1

7. Number of heavy atoms: 15

8. Surface charge: 0

9. Complexity: 245

10. Number of isotope atoms: 0

11. Determine the number of atomic stereocenters: 1

12. Uncertain number of atomic stereocenters: 0

13. Determine the number of chemical bond stereocenters: 0

14. Number of uncertain chemical bond stereocenters: 0

15. Number of covalent bond units: 1

Properties and stability

1. Long-term exposure will cause coloring. A small amount of indole is produced when heated with water. A large amount of indole is produced when heated in the presence of sodium hydroxide or copper sulfate. It is more stable when heated with acid in a dark place. It is easily decomposed when coexisting with other amino acids, sugars and aldehydes.

2. Exist in burley tobacco leaves and smoke.

Storage method

Stored in a sealed, cool, dry and dark place

Synthesis method

1. Chemical synthesis

2.Fermentation method of adding precursors

3 .Direct fermentation method

4. It can be refined from casein through alkaline hydrolysis, or synthesized from β-indole aldehyde and hippuric acid.


1. Nutritional and biochemical research. Prepare tissue culture medium.

2.Amino acid drugs. For amino acid infusion. Often combined with iron supplements, vitamins, etc. Used in combination with vitamin B6 to improve depression and prevent and treat pellagra; used as an insomnia sedative in combination with L-dopa to treat Parkinson’s disease; also used in vitamin B6 deficiency tests.


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